Results A total of 32 randomized clinical trials with 8400 unique participants were included. Main Outcomes and Measures Adverse events, serious adverse events (SAEs), and/or levels of 25-hydroxyvitamin D, calcium, alkaline phosphatase, phosphate, parathyroid hormone, and/or the ratio of urine calcium to creatinine levels. Summary risk ratio (RR), 95% CI, and P values were derived from random-effects meta-analysis.
Study Selection Randomized clinical trials of high-dose vitamin D supplementation in children aged 0 to 6 years, defined as greater than 1000 IU/d for infants (aged 0-1 year) and greater than 2000 IU/d for children aged 1 to 6 years.ĭata Extraction and Synthesis Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses ( PRISMA) reporting guideline, 2 reviewers independently extracted the data from the eligible studies. Objective To systematically assess the risk of adverse events after high-dose supplementation with vitamin D reported in published randomized clinical trials.ĭata Sources PubMed and were searched through August 24, 2021. Importance Several health benefits of vitamin D have been suggested however, the safety of high-dose supplementation in early childhood is not well described. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.
Challenges in Clinical Electrocardiography.
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